Septra, Bactrim Linked to 'Serious' Side EffectsUploader: Taukora 4 years ago Subscribe 3
Trimethoprim-sulfamethoxazole also affects renal clearance of several drugs, including methotrexate. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Follow your doctor's orders or the directions on the label. During treatment, adequate fluid intake and urinary output should be ensured to prevent crystalluria.